Recombinant Human TLR2 Protein(His Tag)

SKU: PDMH100206

Size:100μg

Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping:This product is provided as lyophilized powder which is shipped with ice packs.

Exp date:12 months

Category ID_II:Recombinant Proteins

Category ID_III:Others

Abbreviation:TLR2

Target Synonym:CD282;CD282 antigen;TIL 4;TIL4;TLR 2;TLR2;TLR2;Toll like receptor 2;Toll like receptor 2 precursor;Toll-like receptor 2;Toll/interleukin 1 receptor like 4;Toll/interleukin 1 receptor like protein 4;Toll/interleukin receptor like protein 4;Toll/interleukin-1 receptor-like protein 4

Research Areas:Immunology;Microbiology;Signal Transduction;Cardiovascular

Conjugation:

Target Species:Human

Expression Host:Mammalian

Application:

Fusion tag:C-His

UNIProt ID:O60603

Accession:O60603

Background:The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB.

Concentration:

Activity:Not validated for activity

Sequence:Glu21-Leu590

Purity: > 90% as determined by reducing SDS-PAGE.

Formulation:Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Reconstitution:It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Endotoxin:< 1.0 EU/mg of the protein as determined by the LAL method.

Calculated MW:62.5 kDa

ObservedMW:70-80 kDa