Recombinant human TARC Protein(Fc Tag)

SKU: PDMH100260

Size:100μg

Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping:This product is provided as lyophilized powder which is shipped with ice packs.

Exp date:12 months

Category ID_II:Recombinant Proteins

Category ID_III:Others

Abbreviation:TARC

Target Synonym:A-152E5.3;A152E53;ABCD 2;ABCD2;C-C motif chemokine 17;CC chemokine TARC;CCL17;CCL17;Chemokine CC Motif Ligand 17;MGC138271;MGC138273;SCYA17;Small Inducible Cytokine A17;Small Inducible Cytokine A17 Precursor;Small Inducible Cytokine Subfamily A (Cys Cys);Small Inducible Cytokine Subfamily A (Cys Cys) Member 17;Small-inducible cytokine A17;T Cell Directed CC Chemokine;Thymus and activation regulated chemokine;Thymus and activation-regulated chemokine

Research Areas:Cancer;Immunology

Conjugation:

Target Species:human

Expression Host:Mammalian

Application:

Fusion tag:C-Fc

UNIProt ID:Q92583

Accession:Q92583

Background:Chemokines are a family of small chemotactic cytokines, or proteins secreted by cells. Chemokines share the same structure similarities such as small size, and the presence of four cysteine residues in conserved locations in order to form their 3-dimensional shape. Some of the chemokines are considered pro-inflammatory which can be induced to recruit cells of the immune system to a site of infection during an immune response, while others are considered homeostatic and are implied in controlling the migration of cells during normal processes of tissue maintenance and development. There are four members of the chemokine family: C-C kemokines, C kemokines, CXC kemokines and CX3C kemokines. The C-C kemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands-1 to 28. Chemokin ligand 17 (CCL17), also known as thymus and activation regulated chemokine(TARC), is a small cytokine belonging to the C-C chemokine family. CCL17 is expressed maily in thymus and transiently in phytohemagglutinin-stimulated peripheral blood mononuclear cells. CCL17 can induce chemotaxis in T cells by binding with the chemokine receptor CCR4.

Concentration:

Activity:Not validated for activity

Sequence:Met 1-Ser 94

Purity: > 90% as determined by reducing SDS-PAGE.

Formulation:Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Reconstitution:It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Endotoxin:< 1.0 EU/mg of the protein as determined by the LAL method.

Calculated MW: 35.2 kDa

ObservedMW:36 kDa