Recombinant Human PGD2 Synthase/PTGDS Protein (His Tag)

SKU: PKSH032006

Size: 100μg

Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Exp date: 12 months

Category ID_II: Recombinant Proteins

Category ID_III: Others

Abbreviation:

Target Synonym: Beta-Trace Protein;Cerebrin-28;Glutathione-Independent PGD Synthase;Lipocalin-Type Prostaglandin-D Synthase;PDS;PGD2 Synthase;PGDS;PGDS2;PTGDS;Prostaglandin D Synthase;Prostaglandin-D2 Synthase;Prostaglandin-H2 D-Isomerase

Research Areas: Signal Transduction;

Conjugation:

Target Species: Human

Expression Host: HEK293 Cells

Application:

Fusion tag: C-His

UNIProt ID: P41222

Accession: P41222

Background: PTGDS; also known as L-PGDS; belongs to the calycin superfamily;lipocalin family. Lipocalins share limited regions of sequence homology and a common tertiary structure architecture. They transport small hydrophobic molecules such as steroids; bilins; retinoids; and lipids. PTGDS is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of PGH2 to PGD2. It is involved in smooth muscle contraction/relaxation and a variety of central nervous system functions. PTGDS may have an anti-apoptotic role in oligodendrocytes. It binds small non-substrate lipophilic molecules; including biliverdin; bilirubin; retinal; retinoic acid and thyroid hormone; and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.

Concentration:

Activity: Not validated for activity

Sequence: Met 1-Gln190

Purity: > 80 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Please refer to the printed manual for detailed information.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 20.1 kDa

ObservedMW: 28 kDa