Recombinant Human Pentraxin 3/TSG-14 Protein(His Tag)

SKU: PDMH100346

Size:100μg

Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping:This product is provided as lyophilized powder which is shipped with ice packs.

Exp date:12 months

Category ID_II:Recombinant Proteins

Category ID_III:Others

Abbreviation:Pentraxin 3/TSG-14

Target Synonym:PTX;Pentraxin;TNFAIP;PTX3/TSG;TSG;PTX3;TNFAIP5;TSG-14;long;Pentraxin 3;PTX3/TSG-14;TNF-inducible gene 14 protein;TSG14;AI607804;long;TNF-inducible gene 14 protein;Pentaxin 3;Pentaxin-related protein PTX3;Pentraxin 3 long;Pentraxin-related gene;Pentraxin-related gene rapidly induced by IL-1 beta;Pentraxin-related protein PTX3;TNF alpha-induced protein 5;TSG-14;Pentraxin 3;Tumor necrosis factor alpha-induced protein 5;Tumor necrosis factor-inducible gene 14 protein;Tumor necrosis factor-inducible protein TSG-14

Research Areas:Cardiovascular;Immunology;Cancer

Conjugation:

Target Species:Human

Expression Host:Mammalian

Application:

Fusion tag:C-His

UNIProt ID:P26022

Accession:P26022

Background:Pentraxin-related protein PTX3, also known as Tumor necrosis factor alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein, TSG-14, PTX3 and TNFAIP5, is a secreted protein that contains one pentaxin domain. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. Pentraxins are a family of evolutionarily conserved multifunctional pattern-recognition proteins characterized by a cyclic multimeric structure. Based on the primary structure of the subunit, the pentraxins are divided into two groups: short pentraxins and long pentraxins. C-reactive protein (CRP) and serum amyloid P-component (SAP) are the two short pentraxins. The prototype protein of the long pentraxin group is pentraxin 3 (PTX3). CRP and SAP are produced primarily in the liver in response to IL-6, while PTX3 is produced by a variety of tissues and cells and in particular by innate immunity cells in response to proinflammatory signals and Toll-like receptor (TLR) engagement. PTX3 is essential in female fertility by acting as a nodal point for the assembly of the cumulus oophorus hyaluronan-rich extracellular matrix. PTX3 interacts with several ligands, including growth factors, extracellular matrix components and selected pathogens, playing a role in complement activation and facilitating pathogen recognition by phagocytes, acting as a predecessor of antibodies. PTX3 may also contribute to the pathogenesis of atherosclerosis.

Concentration:

Activity:Not validated for activity

Sequence:Glu18-Ser381

Purity: > 90% as determined by reducing SDS-PAGE.

Formulation:Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Reconstitution:It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Endotoxin:< 1.0 EU/mg of the protein as determined by the LAL method.

Calculated MW:39.9 kDa

ObservedMW:45 kDa