Recombinant Human IP-10/CXCL10 protein

SKU: CD01442

Size:5 ug

Background:CXCL10 also known as IP-10 is belonging to the CXC chemokine family. It is encoded by the CXCL10 gene. CXCL10 was originally identified in monocytes, endothelial cells and fibroblasts as a responsor to IFN-γ. This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3. CXCL10 has been shown to be a chemoattractant for activated T-lymphocytes and monocytes/macrophages. It also has other roles, such as promotion of T cell adhesion to endothelial cells, and inhibition of bone marrow colony formation and angiogenesis. The mouse homologue of human IP-10, Crg-2, has been cloned and shown to share approximately 67 % amino acid sequence identity with human IP-10.

Research_area:Immunology

Purity:> 97 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Human gamma-Interferon Inducible Protein 10/CXCL10

Biological activity:Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood T-lymphocytes is in a concentration range of 1-5 ng/ml.

Synonyms:IP-1/CXCL1, C7, IFI1, INP1, IP-1, SCYB1, crg-2, gIP-1, mob-1,Human

Endotoxin:Less than 1 EU/μg of rHuIP-10/CXCL10 as determined by LAL method.

Storage:-20ºC

Sequence:VPLSRTVRCT CISISNQPVN PRSLEKLEII PASQFCPRVE IIATMKKKGE KRCLNPESKA IKNLLKAVSK EMSKRSP

uniprot accession:P2778

Molecular weight:Approximately 8.6 kDa, a single non-glycosylated polypeptide chain containing 77 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in 2 mM PB, pH 7.4, 5 mM NaCl.