Recombinant Human IL22 N terminal protein (Avi,His tag)

SKU: PDEH100867

Size:100μg

Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping:This product is provided as lyophilized powder which is shipped with ice packs.

Exp date:12 months

Category ID_II:Recombinant Proteins

Category ID_III:Others

Abbreviation:IL22 N terminal

Target Synonym:UNQ;IL-D;Interleukin;Cytokine Zcyto;TIFIL;zcyto;IL22;IL-21;IL-22;IL-D110;IL-TIF;ILTIF;TIFIL-23;TIFa;zcyto18;UNQ3099/PRO10096;UNQ3099;Interleukin-22;Cytokine Zcyto18;IL-10-related T-cell-derived-inducible factor;PRO10096;IL-D110;ILTIF;IL-TIF;TIFa;TIFIL-23;zcyto18

Research Areas:immunology

Conjugation:Biotinylated

Target Species:Human

Expression Host:E.coli

Application:

Fusion tag:C-Avi-His

UNIProt ID:Q9GZX6

Accession:Q9GZX6

Background:Interleukin-22(IL-22) is a member of a group of the IL-10 family, a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells. IL-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction. It can initiate and regulate innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 along with IL-17 likely plays a role in the coordinated response of both adaptive and innate immune systems. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. Biological activity of IL-22 is initiated by binding to a cell-surface complex consisting of IL-22R1 and IL-10R2 receptor chains. IL-22 biological activity is further regulated by interactions with a soluble binding protein, IL-22BP. IL-22BP and an extracellular region of IL-22R1 share sequence similarity. In some cases, the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by cytokine IL-17A.

Concentration:

Activity:Not validated for activity

Sequence:Gln 29-Asp 109

Purity: > 95% as determined by reducing SDS-PAGE.

Formulation:Lyophilized from sterile PBS, pH 7.4.
Normally 5%-8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution:It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Endotoxin:< 10 EU/mg of the protein as determined by the LAL method.

Calculated MW:8.8 kDa

ObservedMW:15 kDa