Recombinant Human IL-28B/IFN-lambda-3 protein (His tag)

SKU: PDEH100915

Size:100μg

Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping:This product is provided as lyophilized powder which is shipped with ice packs.

Exp date:12 months

Category ID_II:Recombinant Proteins

Category ID_III:Others

Abbreviation:IL-28B;IFN-lambda-3

Target Synonym:Cytokine Zcyto;ZCYTO;IFNL3;IFN-lambda-3;IFN-lambda-4;IL-28B;IL-28C;IL28B;IL28C;Cytokine Zcyto22;IFNL4;IFN-lambda 3;interferon lambda 3;Interferon Lambda-3;Interferon Lambda-4;Interleukin-28B;Interleukin-28C;ZCYTO22

Research Areas:Signal Transduction;Microbiology;immunology

Conjugation:

Target Species:Human

Expression Host:E.coli

Application:

Fusion tag:N-His

UNIProt ID:Q8IZI9

Accession:Q8IZI9

Background:Interleukin-28B, also known as Cytokine Zcyto22, Interferon lambda-3, Interferon lambda-4, IFNL3, IFNL4, ZCYTO22 and IL28B, is a secreted cytokine which belongs to the IL-28/IL-29 family. IL-28 has also been shown to play a role in the adaptive immune response. IL28B has immunomodulatory activity and up-regulates MHC class I antigen expression. IL28B displays potent antiviral activity and antitumor activity. In addition, IL28B is a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway.

Concentration:

Activity:Not validated for activity

Sequence:Val 22-Val 196

Purity: > 95% as determined by reducing SDS-PAGE.

Formulation:Lyophilized from sterile PBS, pH 7.4.
Normally 5%-8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution:It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Endotoxin:< 10 EU/mg of the protein as determined by the LAL method.

Calculated MW:19.1 kDa

ObservedMW:25 kDa