Recombinant Human IFNAR1/IFNAR Protein (Fc Tag)

SKU: PKSH030696

Size: 100μg

Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Exp date: 12 months

Category ID_II: Recombinant Proteins

Category ID_III: Others

Abbreviation:

Target Synonym: AVP;CRF2-1;Cytokine Receptor Class-II Member 1;Cytokine Receptor Family 2 Member 1;IFN-Alpha/Beta Receptor 1;IFN-R-1;IFN-alpha-REC;IFNAR;IFNAR1;Interferon Alpha/Beta Receptor 1;Type I Interferon Receptor 1

Research Areas: Immunology,Signal Transduction,Epigenetics and Nuclear Signaling

Conjugation:

Target Species: Human

Expression Host: HEK293 Cells

Application:

Fusion tag: C-hFc

UNIProt ID: P17181

Accession: P17181-1

Background: Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases; which in turn phosphorylate several proteins; including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due; at least in part; to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1; in which Tyr466 is changed to phenylalanine; can act in a dominant negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors.

Concentration:

Activity: Not validated for activity

Sequence: Met 1-Lys 436

Purity: > 88 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Please refer to the printed manual for detailed information.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 74.0 kDa

ObservedMW: 100-120 kDa