Recombinant Human DKK-3 Protein(His Tag)

SKU: PDMH100318

Size:100μg

Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping:This product is provided as lyophilized powder which is shipped with ice packs.

Exp date:12 months

Category ID_II:Recombinant Proteins

Category ID_III:Others

Abbreviation:DKK-3

Target Synonym:UNQ;PRO;Dickkopf-Related Protein;hDkk;Dickkopf;DKK;DKK3;REIC;RIG;Dickkopf-3;Dickkopf-Related Protein 3;Dkk-3;hDkk-3;UNQ258;PRO295;Dickkopf 3;Dickkopf 3 homolog;Dickkopf 3 homolog (Xenopus laevis);Dickkopf homolog 3;Dickkopf related protein 3;Dickkopf related protein 3 Precursor;Dickkopf WNT signaling pathway inhibitor 3;Dickkopf3;DKK 3;hDkk 3;hDkk3;homolog of;Regulated in glioma;RIG-like 5-6;RIG-like 7-1;Xenopus

Research Areas:Signal Transduction;Stem Cells

Conjugation:

Target Species:Human

Expression Host:Mammalian

Application:

Fusion tag:C-His

UNIProt ID:Q9UBP4

Accession:Q9UBP4

Background:DKK3 (dickkopf related protein 3) is a member of the dickkopf-related family consisting of DKK1 , DKK2 , DKK3 and DKK4. It is a secreted protein , and also known as REIC (Reduced Expansion in Immortalized Cells). The DKK3 protein is proposed to function as a secreted tumor suppressor since it is downregulated in a number of cancer cells and prostate cancer tissue and may be a promising candidate molecule for therapeutic interference. DKK3 protein is also a negative regulator of beta-catenin and its downregulation contribute to an activation of the beta-catenin signaling pathway.

Concentration:

Activity:Not validated for activity

Sequence:Ala22-Ile350

Purity: > 90% as determined by reducing SDS-PAGE.

Formulation:Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Reconstitution:It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Endotoxin:< 1.0 EU/mg of the protein as determined by the LAL method.

Calculated MW:36.0 kDa

ObservedMW:50 kDa