Recombinant Human Cu/Zn SOD protein (His Tag)

SKU: CD01967

Size:20 ug

Background:Superoxide dismutase catalyzes the reaction between superoxide anions and hydrogen to yield molecular oxygen and hydrogen peroxide. Cu/Zn superoxide dismutase also named as SOD1, is an enzyme encoded by the SOD1 gene in humans, located on chromosome 21. The SOD1 binds Cu and Zn ions and is one of three SODs responsible for destroying free superoxide radicals in the body. It has been shown to interact with CCS and Bcl-2. The malfunction of SOD1 may increase the risk of illnesses like age-related muscle mass loss (sarcopenia), early development of cataracts, macular degeneration, thymic involution, hepatocellular carcinoma, shortened lifespan, keratoconus and amyotrophic lateral sclerosis.

Research_area:Others

Purity:> 95 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Human Cu/Zn Superoxide Dismutase, His

Biological activity:Fully biologically active when compared to standard. The potency per mg was determined by Pyrogallic Acid method and was found to be more than 1. × 14 IU/mg.

Synonyms:Cu/Zn SOD, His-tagged, ALS, ALS1, HEL-S-44, IPOA, SOD, STAHP, hSod1, homodimer,Human

Endotoxin:Less than 1 EU/μg of rHuCu/Zn SOD, His as determined by LAL method.

Storage:-20ºC

Sequence:MGHHHHHHHH HHSSGHIEGR HMTYARAAAR QARALEATKA VCVLKGDGPV QGIINFEQKE SNGPVKVWGS IKGLTEGLHG FHVHEFGDNT AGCTSAGPHF NPLSRKHGGP KDEERHVGDL GNVTADKDGV ADVSIEDSVI SLSGDHCIIG RTLVVHEKAD DLGKGGNEES TKTGNAGSRL ACGVIGIAQ

uniprot accession:P441;P8294

Molecular weight:Approximately 39.9 kDa, a homodimer, non-glycosylated polypeptide chain containing 2 × 189 amino acids with Met, Gly and 1 × His at N-terminus.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in PBS, pH 7.4.