Recombinant Human Cu/Zn SOD protein

SKU: CD01968

Size:20 ug

Background:Superoxide dismutase catalyzes the reaction between superoxide anions and hydrogen to yield molecular oxygen and hydrogen peroxide. Cu/Zn superoxide dismutase also named as SOD1, is an enzyme encoded by the SOD1 gene in humans, located on chromosome 21. The SOD1 binds Cu and Zn ions and is one of three SODs responsible for destroying free superoxide radicals in the body. It has been shown to interact with CCS and Bcl-2. The malfunction of SOD1 may increase the risk of illnesses like age-related muscle mass loss (sarcopenia), early development of cataracts, macular degeneration, thymic involution, hepatocellular carcinoma, shortened lifespan, keratoconus and amyotrophic lateral sclerosis.

Research_area:Others

Purity:> 95 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Human Cu/Zn Superoxide Dismutase

Biological activity:Fully biologically active when compared to standard. The potency per mg was determined by Pyrogallic Acid method and was found to be more than 1. × 14 IU/mg.

Synonyms:Cu/Zn SOD,ALS, ALS1, HEL-S-44, IPOA, SOD, STAHP, hSod1, homodimer, Human

Endotoxin:Less than 1 EU/μg of rHuCu/Zn SOD as determined by LAL method.

Storage:-20ºC

Sequence:ATKAVCVLKG DGPVQGIINF EQKESNGPVK VWGSIKGLTE GLHGFHVHEF GDNTAGCTSA GPHFNPLSRK HGGPKDEERH VGDLGNVTAD KDGVADVSIE DSVISLSGDH CIIGRTLVVH EKADDLGKGG NEESTKTGNA GSRLACGVIG IAQ

uniprot accession:P441;P8294

Molecular weight:Approximately 31.6 kDa, a homodimer, non-glycosylated polypeptide chain containing 2 × 153 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in PBS, pH 7.4.