Recombinant Human BNP protein

SKU: CD02235

Size:20 ug

Background:Brain Natriuretic Peptide is encoded by the BNP gene located on the Chr.1 in humans. It is firstly discovered in the porcine brain and given this name, but the protein is mainly expressed in the cardiac ventricles in human body after the excessive stretching of cardiomyocytes. The gene expresses a 134 a.a. sequence which contains a 1-26 a.a. signal peptide and 27-134 a.a. Natriuretic peptides B, and the BNP is the 32 a.a. C-terminus of natriuretic peptides B. The BNP can be cleaved in 16 chains and the rHuBNP is 1-32. BNP acts as a cardiac hormone with a variety of functions including natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Additionnaly, it plays a key role in cardiovascular homeostasis, helps restore the bodys salt and water balance and improves heart function.

Research_area:Immunology

Purity:> 97 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Human Brain Natriuretic Peptide

Biological activity:Data Not Available.

Synonyms:BNP, BNP, Iso-ANP,Human

Endotoxin:Less than 1 EU/μg of rHuBNP as determined by LAL method.

Storage:-20ºC

Sequence:SPKMVQGSGC FGRKMDRISS SSGLGCKVLR RH

uniprot accession:P1686

Molecular weight:Approximately 3.5 kDa, a single non-glycosylated polypeptide chain containing 32 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in PBS, pH 7.4.