Recombinant Human BMP-7 protein

SKU: CD02239

Size:2 ug

Background:Bone Morphogenetic Protein 7 is one of the BMPs, some of which belong to the TGF-beta superfamily (BMP2-7). There are more than thirteen BMPs have been discovered nowadays and they are involved in inducing cartilage and bone formation. BMP-7 is mainly expressed in kidney and bladder. It is also present in developing eyes, brain and ear during embryogenesis. BMP-7 also named osteogenic protein-1 (OP-1) is a potent osteoinductive cytokine and plays role in osteoblast differentiation, SMAD1 production and renal development and repair. Human BMP-7 is synthesized with a signal sequence (29 a.a.), a propeptide (263 a.a.), and a growth factor domain (139 a.a.). The growth factor domain of human BMP-7 shares 98 % a.a. sequence identity with mouse and rat BMP-7.

Research_area:Immunology

Purity:> 95 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Human Bone Morphogenetic Protein 7

Biological activity:Data is not available.

Synonyms:BMP-7, OP-1,BMP7,Human

Endotoxin:Less than 1 EU/μg of rHuBMP-7 as determined by LAL method.

Storage:-20ºC

Sequence:STGSKQRSQN RSKTPKNQEA LRMANVAENS SSDQRQACKK HELYVSFRDL GWQDWIIAPE GYAAYYCEGE CAFPLNSYMN ATNHAIVQTL VHFINPETVP KPCCAPTQLN AISVLYFDDS SNVILKKYRN MVVRACGCH

uniprot accession:P1875

Molecular weight:Approximately 15.7 kDa, a monomeric, non-glycosylated polypeptide chain containing 139 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in 3 % acetonitrile, .1 % TFA.