Recombinant Human ALK-1 Protein(Fc Tag)

SKU: PDMH100306

Size:100μg

Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping:This product is provided as lyophilized powder which is shipped with ice packs.

Exp date:12 months

Category ID_II:Recombinant Proteins

Category ID_III:Others

Abbreviation:ALK-1

Target Synonym:SKR;ORW;Activin Receptor-Like Kinase;Serine/Threonine-Protein Kinase Receptor R;ACVRL;ACVRLK;ALK;ACVRL1;ACVRLK1;ALK-1;ALK1;HHT;HHT2;ORW2;SKR3;TSR-I;Activin Receptor-Like Kinase 1;Serine/Threonine-Protein Kinase Receptor R3;TGF-B Superfamily Receptor Type I

Research Areas:Cardiovascular;Signal Transduction;Metabolism

Conjugation:

Target Species:Human

Expression Host:Mammalian

Application:

Fusion tag:C-Fc

UNIProt ID:P37023

Accession:P37023

Background:Activin A receptor , type II-like 1 (ACVRL1) , also known as ALK-1 (activin receptor-like kinase 1) , is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. On ligand binding , a heteromeric receptor complex forms consisting of two type II and two type I transmembrane serine/threonine kinases. ACVRL1 protein is expressed in certain blood vessels of kidney , spleen , heart and intestine , serving as an important role during vascular development. Mutations in ACVRL1 gene are associated with hemorrhagic telangiectasia type 2 , also known as Rendu-Osler-Weber syndrome 2 and vascular disease.

Concentration:

Activity:Not validated for activity

Sequence:Asp22-Gln118

Purity: > 90% as determined by reducing SDS-PAGE.

Formulation:Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Reconstitution:It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Endotoxin:< 1.0 EU/mg of the protein as determined by the LAL method.

Calculated MW:35.5 kDa

ObservedMW:50 kDa