Recombinant GCLC Monoclonal Antibody

SKU: AN300793L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:GCLC

Target Synonym:GSH;Glutamate cysteine ligase catalytic subunit;GCLC;GCL;GCS;GLCL;GLCLC;EC 6.3.2.2;Gamma ECS;Gamma glutamylcysteine synthetase;Gamma-ECS;Gamma-glutamylcysteine synthetase;GCS heavy chain;Glutamate cysteine ligase catalytic subunit;Glutamate--cysteine ligase catalytic subunit;GSH1;GCSc-γ

Research Areas:Signal Transduction;Cell Biology;Metabolism

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:3G3

UNIProt ID:P48506

Accession:

Background:Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human GCLC protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:WB 1:2000-1:10000;

Calculated MW:73 kDa

ObservedMW:73 kDa