Recombinant ELNE Monoclonal Antibody

SKU: AN301296L

Size::

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:ELNE

Target Synonym:SCN;ELA;Elastase;ELANE;ELA2;GE;HLE;HNE;NE;PMN-E;SCN1;Elastase-2;Medullasin;Neutrophil elastase;Bone marrow serine protease;Human leukocyte elastase;PMN elastase;Elastase 2;Elastase 2 neutrophil;Elastase neutrophil expressed;ELNE;Granulocyte derived elastase;Leukocyte elastase;Neutrophil expressed;PMN E;Polymorphonuclear elastase

Research Areas:Immunology;Microbiology;Signal Transduction;Cancer;Kits;Lysates;Other

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:5C7

UNIProt ID:P08246

Accession:

Background:Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human ELNE protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:WB 1:2000-1:10000;

Calculated MW:29 kDa

ObservedMW:30 kDa