Recombinant Drosha Monoclonal Antibody

SKU: AN301162L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:Drosha

Target Synonym:ETOHI;DROSHA;ETOHI2;HSA242976;RANSE3L;RN3;RNASE3L;RNASEN;Drosha double stranded RNA specific endoribonuclease;Drosha ribonuclease type III;Nuclear RNase III Drosha;p241;Protein Drosha;Putative protein p241 which interacts with transcription factor Sp1;Putative ribonuclease III;Ribonuclease 3;Ribonuclease III;Ribonuclease III nuclear;Ribonuclease type III nuclear;RibonucleaseIII;RN 3;RNase 3;RNase III;RNase3;RnaseⅢ;RNaseIII;RNC;Drosha

Research Areas:Epigenetics and Nuclear Signaling

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB;IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:11G11

UNIProt ID:Q9NRR4

Accession:

Background:DROSHA(drosha ribonuclease III) Homo sapiens This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human Drosha protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:IHC 1:200-1:1000;WB 1:2000-1:10000

Calculated MW:159 kDa

ObservedMW:159 kDa