Recombinant Cyclin E1 Monoclonal Antibody

SKU: AN301091L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:Cyclin E1

Target Synonym:G1/S-specific cyclin-E;pCCNE;cyclin E;CCNE1;CCNE;pCCNE1;cyclin E1;cyclin E variant ex5del;cyclin E variant ex7del;Cyclin Es;Cyclin Et;CyclinE;G1/S specific cyclin E;G1/S-specific cyclin-E1

Research Areas:Cell Biology;Epigenetics and Nuclear Signaling;Cancer

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB;IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:6G15

UNIProt ID:P24864

Accession:

Background:The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human Cyclin E1 protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:IHC 1:400-1000;WB 1:1000-5000

Calculated MW:47 kDa

ObservedMW:47 kDa