Recombinant CTCF Monoclonal Antibody

SKU: AN300709L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:CTCF

Target Synonym:MRD;Cancer/testis antigen;CTCF;MRD21;11-Zinc Finger Protein;BORIS;Brother of the regulator of imprinted sites;Cancer/testis antigen 27;CCCTC-Binding Factor;CT27;CTCF paralog;CTCFL;CTCFL Paralog;CTCF-like protein;Transcriptional Repressor CTCF;Transcriptional repressor CTCFL;Zinc finger protein CTCF-T

Research Areas:Epigenetics and Nuclear Signaling

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:12G4

UNIProt ID:P49711

Accession:

Background:This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human CTCF protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:WB 1:2000-1:10000

Calculated MW:83 kDa

ObservedMW:140 kDa