Recombinant Chk2 Monoclonal Antibody

SKU: AN300955L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:Chk2

Target Synonym:RAD;LFS;CHK;CDS;hCds;CHEK;HuCds;CDS1;CHK2;HuCds1;LFS2;PP1425;RAD53;hCds1;CHEK2;CDS 1;Cds1 homolog;Checkpoint kinase 2;Checkpoint like protein CHK2;CHEK 2;Chk 2;CHK2 checkpoint homolog;CHK2 checkpoint homolog (S. pombe);HuCds 1;LFS 2;RAD 53;Rad53 homolog;Serine/threonine protein kinase Chk2;Serine/threonine-protein kinase Chk2

Research Areas:Epigenetics and Nuclear Signaling;Cancer

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:5F3

UNIProt ID:O96017

Accession:

Background:In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human Chk2 protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:WB 1:1000-1:5000

Calculated MW:61 kDa

ObservedMW:61 kDa