Recombinant CD180/RP105 Monoclonal Antibody

SKU: AN300524P

Size::

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:CD180

Target Synonym:Ly78;Rp105;Cd180;Ly-78;F630107B15

Research Areas:

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Mouse

Application:IHC-P

Isotype:IgG

Clonality:Monoclonal

Clone NO.:8A3

UNIProt ID:Q62192

Accession:

Background:The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD180, also known as RP105, is a B-cell surface molecule belonging to the family of pathogen receptors, Toll-like receptors (TLR). CD180 has an extracellular leucine-rich repeats and a short cytoplasmic tail. CD180/RP105 interacts with an extracellular molecule named MD1 and then together form the cell surface receptor complex RP105/MD1 which induces B-cell activation in humans and mice, leading to proliferation and up-regulation of a costimulatory molecule, B7.2/CD86. CD180/RP105 also has a role in LPS response because B cells lacking RP105 show hyporesponsiveness to LPS.

Concentration:1 mg/mL

Immunogen:Recombinant Mouse CD180/RP105 Protein

Buffer:0.2 μm filtered solution in PBS

Purification method:Protein A

Dilution:IHC-P 1:50-1:200

Calculated MW:

ObservedMW: