Recombinant CD166/ALCAM Monoclonal Antibody

SKU: AN300586P

Size::

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:ALCAM

Target Synonym:UCHL;Uchl1;HEL-117;HEL-S-53;NDGOA;PARK5;PGP 9.5;PGP9.5;PGP95;SPG79;Ubiquitin C-terminal hydrolase L1;Uch-L1

Research Areas:

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Rat

Application:WB;IP

Isotype:IgG

Clonality:Monoclonal

Clone NO.:11B8

UNIProt ID:Q00981

Accession:

Background:Activated leukocyte cell adhesion molecule (ALCAM)/Cluster of differentiation (CD166) is a type I transmembrane cell adhesion molecule belonging to the Ig superfamily and a ligand for CD6 that is expressed on T lymphocytes. The extracellular domain of ALCAM contains five Ig-like domains (three Ig-like C2-type domains and two Ig-like V-type domains), of which the amino-terminal V1 domain is essential for ligand binding and ALCAM-mediated cell aggregation. ALCAM mediates both heterophilic (ALCAM-CD6) and homophilic (ALCAM-ALCAM) cell-cell interactions. ALCAM/CD6 interaction plays a role in T cell development and T cell regulation, as well as in the binding of T- and B-cells to activated leukocytes. Recently, homophilic (ALCAM-ALCAM) adhesion was shown to play important roles in tight cell-to-cell interaction and regulation of stem cell differentiation. While expressed in a wide variety of tissues, ALCAM is usually restricted to subsets of cells involved in dynamic growth and/or migration, including neural development, branching organ development, hematopoiesis, immune response and tumor progression. And CD166 is regarded as a potential novel breast cancer indicator and therapeutic target.

Concentration:1 mg/mL

Immunogen:Recombinant Rat CD166/ALCAM protein

Buffer:0.2 μm filtered solution in PBS

Purification method:Protein A

Dilution:WB 1:500-1:2000;IP 1-4 μL/mg of lysate

Calculated MW:65 kDa

ObservedMW:100 kDa