Recombinant CD112/Nectin-2/PVRL2 Monoclonal Antibody

SKU: AN300508P

Size::

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:NECTIN2

Target Synonym:Pvrl;NECTIN;Mph;Pvr;Pvrl2;Pvs;Nectin2;PRR2;Nectin-2;AI325026 Protein;AI987993 Protein;CD112;Cd112 Protein;Herpes virus entry mediator B;Herpesvirus entry mediator B;HveB;MPH Protein;NECT2;Nectin cell adhesion molecule 2;Nectin-2;nectin-2 Protein;Poliovirus receptor-related protein 2;Pvr Protein;Pvs Protein

Research Areas:

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Mouse

Application:WB;IP

Isotype:IgG

Clonality:Monoclonal

Clone NO.:8C12

UNIProt ID:P32507

Accession:

Background:Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell to cell spreading of these viruses. CD112 protein has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 protein can induce NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. CD112 has been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy.

Concentration:1 mg/mL

Immunogen:Recombinant Mouse PVRL2 protein

Buffer:0.2 μm filtered solution in PBS

Purification method:Protein A

Dilution:WB 1:500-1:1000;IP 0.2-1 μL/mg of lysate

Calculated MW:58 kDa

ObservedMW:58 kDa