Recombinant Activin A Receptor Type IB/ALK-4 Monoclonal Antibody

SKU: AN301427L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:Activin A Receptor Type IB/ALK-4

Target Synonym:SKR;Activin Receptor-Like Kinase;Serine/Threonine-Protein Kinase Receptor R;ACVRLK;ALK;ACVR1B;ACTRIB;ACVRLK4;ALK4;SKR2;Activin Receptor Type IB;Activin Receptor Type-1B;Activin Receptor-Like Kinase 4;ACTR-IB;ALK-4;Serine/Threonine-Protein Kinase Receptor R2

Research Areas:Signal Transduction;Stem Cells

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse

Application:WB;IF

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A122

UNIProt ID:P36896

Accession:

Background:Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail.

Concentration:1 mg/mL

Immunogen:Recombinant human Activin A Receptor Type IB/ALK-4 fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:500-1:1000;IF 1:50

Calculated MW:52 kDa

ObservedMW:55 kDa