Recombinant ABL1 Monoclonal Antibody

SKU: AN300847L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:ABL1

Target Synonym:JTK;Tyrosine-protein kinase ABL;Abelson tyrosine-protein kinase;Abelson murine leukemia viral oncogene homolog;ABL;JTK7;p150;c-ABL;v-abl;CHDSKM;c-ABL1;ABL1;bcr/abl;JTK7);Tyrosine-protein kinase ABL1;ABL1 (ABL);Abelson murine leukemia viral oncogene homolog 1;Abelson tyrosine-protein kinase 1;Abelson tyrosine protein kinase 1;Abl 1;ABL proto oncogene 1 non receptor tyrosine kinase;bcr/c abl oncogene protein;c ABL;c abl oncogene 1 non receptor tyrosine kinase;c abl oncogene 1 receptor tyrosine kinase;c ABL1;Proto oncogene tyrosine protein kinase ABL1;Proto-oncogene c-Abl;v abl;v abl Abelson murine leukemia viral oncogene homolog 1

Research Areas:Signal Transduction;Epigenetics and Nuclear Signaling;Cancer

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:5H6

UNIProt ID:P00519

Accession:

Background:This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human ABL1 protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:WB 1:2000-1:10000

Calculated MW:123 kDa

ObservedMW:123 kDa