RBBP6 antibody , Cat. # FNab07152

SKU: FNab07152

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome(PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth(By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites(CFSs) in a ZBTB38-and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication(PubMed:24726359).

Immunogen:retinoblastoma binding protein 6

Synonyms:P2PR, PACT, RBQ1

Observed MW:200 kDa

Uniprot ID:Q7Z6E9

Reactivity:Human, Mouse

Tested Application:ELISA, WB

Recommended dilution:WB: 1:500-1:2000

Gene ID:5930

Research Area:Epigenetics, Immunology, Metabolism