Rat Transient Receptor Potential Cation Channel Subfamily A Member 1, TRPA1 ELISA Kit

SKU: E2290Ra

Size:96 Tests-1 Kit

Background:Receptor-activated non-selective cation channel involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function. Shows 8-fold preference for divalent over monovalent cations. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of irritants, such as allylthiocyanate (AITC) found in mustard oil or wasabi, cinnamaldehyde, diallyl disulfide (DADS) from garlic, and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as an ionotropic cannabinoid receptor by being activated by delta9-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:14712238). Is activated by a large variety of structurally unrelated electrophilic and non-electrophilic chemical compounds. Electrophilic ligands activate TRPA1 by interacting with critical N-terminal Cys residues in a covalent manner, whereas mechanisms of non-electrophilic ligands are not well determined. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity).

Research_area:Neuroscience

Applications:ELISA

Target_protein:TRPA1

Reactivity:Rat

Assay type:Sandwich

Sensitivity:0.47ng/L

Detection range:1-400ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Transient receptor potential cation Channel subfamily A member 1

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q6RI86

MASS(Da):128,602

GeneID:312896

Synonyms:Anktm1;Ankyrin-like with transmembrane domains protein 1;Transient receptor potential cation Channel subfamily A member 1;TRPA1;Wasabi receptor

Gene names:Trpa1

Standard solution:480ng/L