Rat TNF Receptor Associated Factor 6,TRAF6 ELISA KIT

SKU: E2551Ra

Size:96 Tests-1 Kit

Background:E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. {ECO:0000250|UniProtKB:Q9Y4K3}.

Research_area:

Applications:ELISA

Target_protein:Traf6

Reactivity:Rat

Assay type:Sandwich

Sensitivity:0.021ng/ml

Detection range:0.05-15ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:TNF Receptor Associated Factor 6

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:B5DF45

MASS(Da):60253

GeneID:311245

Synonyms:Traf6

Gene names:Traf6

Standard solution:16ng/ml