Rat T-cell Surface Glycoprotein Cd3 Delta Chain, CD3D ELISA Kit

SKU: E2274Ra

Size:96 Tests-1 Kit

Background:Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells.

Research_area:Others

Applications:ELISA

Target_protein:CD3D

Reactivity:Rat

Assay type:Sandwich

Sensitivity:0.056ng/mL

Detection range:0.1-40ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:T-cell surface glycoprotein CD3 delta chain

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P19377

MASS(Da):19,356

GeneID:25710

Synonyms:CD antigen CD3d;CD3D;T-cell receptor T3 delta chain;T-cell surface glycoprotein CD3 delta chain

Gene names:Cd3d

Standard solution:48ng/mL