Rat Sarcoplasmic;endoplasmic reticulum calcium ATPase 2,ATP2A2 ELISA KIT

SKU: E1470Ra

Size:96 Tests-1 Kit

Background:This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation. Also modulates ER contacts with lipid droplets, mitochondria and endosomes. {ECO:0000250|UniProtKB:P16615}.; [Isoform 2]: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation. {ECO:0000250|UniProtKB:O55143}.

Research_area:

Applications:ELISA

Target_protein:Atp2a2

Reactivity:Rat

Assay type:Sandwich

Sensitivity:0.015ng/ml

Detection range:0.05-15ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Sarcoplasmic;endoplasmic reticulum calcium ATPase 2

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P11507

MASS(Da):114768

GeneID:29693

Synonyms:Atp2a2

Gene names:Atp2a2

Standard solution:16ng/ml