Rat Ras-related Protein Rab-3A, RAB3A ELISA Kit

SKU: E2440Ra

Size:96 Tests-1 Kit

Background:Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (PubMed:21689256). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (PubMed:18407218). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (PubMed:17149709). Stimulates insulin secretion through interaction with RIMS2 and RPH3AL effectors in pancreatic beta cells (By similarity). Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9 (By similarity). Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1 (By similarity). Plays a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT (PubMed:28057568). Interacts with MADD (via uDENN domain); the GTP-bound form is preferred for interaction (By similarity).

Research_area:Signal Transduction

Applications:ELISA

Target_protein:RAB3A

Reactivity:Rat

Assay type:Sandwich

Sensitivity:4.88ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Ras-related protein Rab-3A

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P63012

MASS(Da):24,970

GeneID:25531

Synonyms:RAB3;RAB3A;Ras-related protein Rab-3A

Gene names:Rab3a

Standard solution:2400ng/L