Rat Myostatin/GDF8 ELISA Kit PicoKine®

SKU: EK1267

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Rat

Applications: ELISA

Application Details:

Gene Name: MSTN

Specificity: Natural and recombinant rat Myostatin/GDF8

Background: Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis: muscle cell growth and differentiation. In humans it is encoded by the MSTN gene. It is mapped to 9q22. Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals.

Immunogen: Expression system for standard: NS0; Immunogen sequence: D268-S376

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Uniprot ID: O35312

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 29152

Protein Name: Growth/differentiation factor 8

Gene Full Name: myostatin

Synonyms: GDF 8; GDF8; MSTN; myostatin