Rat Kininogen-1, KNG1 ELISA Kit

SKU: E1726Ra

Size:96 Tests-1 Kit

Background:(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active Peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.

Research_area:Cardiovascular

Applications:ELISA

Target_protein:KNG1

Reactivity:Rat

Assay type:Sandwich

Sensitivity:3.06ng/ml

Detection range:5-1500ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Kininogen-1

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P08934

MASS(Da):70933

GeneID:25087

Synonyms:Bradykinin;Kininogen-1 Kininogen-1 heavy chain;Kininogen-1 light chain;KNG 1;KNG1

Gene names:KNG1

Standard solution:1600ng/ml