Rat GDNF ELISA Kit PicoKine®

SKU: EK0363

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Rat

Applications: ELISA

Application Details:

Gene Name: GDNF

Specificity: Natural and recombinant rat GDNF

Background: Glial cell line-derived neurotrophic factor (GDNF) is a glycosylated, disulfide-bonded homodimer that is a distantly related member of the transforming growth factor-beta superfamily. GDNF, is a potent neurotrophic factor that promotes the survival of dopaminergic neurones in cultures including embryonic neuronal cultures. GDNF, in addition to its potential role in the differentiation and survival of central nervous system neurons, has profound effects on kidney organogenesis and the development of the peripheral nervous system.3 GDNF may have utility in the treatment of Parkinson's disease, which is marked by progressive degeneration of midbrain dopaminergic neurons. GDNF lies on the short arm of human chromosome 5, at 5p13.1-p13.3 ability to promote dopamine uptake in midbrain cultures. The standard product used in this kit is recombinant rat GDNF, which is a dimmer composed of two chains with 134 amino acids.

Immunogen: Expression system for standard: NS0; Immunogen sequence: S78-I211

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Uniprot ID: Q07731

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 25453

Protein Name: Glial cell line-derived neurotrophic factor

Gene Full Name: glial cell derived neurotrophic factor

Synonyms: GDNF; HFB1 GDNF; hGDNF; ATF; ATF1; ATF2; HFB1-GDNF; HSCR3