Rat Endothelin 2, ET-2 ELISA Kit

SKU: E1006Ra

Size:96 Tests-1 Kit

Background:Endothelin 2 (ET-2) is a protein encoded by the EDN2 gene in humans. It was first discovered in 1988 by Yanagisawa and team and belongs to a family of three endothelin peptide isoforms (ET-1, ET-2, ET-3), which constrict blood vessels. ET-2 is encoded by genes on separate chromosomes to its isoforms and is mainly produced in vascular endothelial cells of the kidney, placenta, uterus, heart, central nervous system and intestine. It becomes present in the blood of animals and humans at levels ranging from 0.3pg/ml to 3pg/ml. ET-2 acts by binding to two different G-protein coupled receptors (GCPRs), the endothelin A receptor (EDNRA) and the endothelin B receptor (EDNRB).

Research_area:Epigenetics and Nuclear Signaling

Applications:ELISA

Target_protein:ET-2

Reactivity:Rat

Assay type:Sandwich

Sensitivity:0.51ng/L

Detection range:1-300ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Endothelin 2

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P23943

MASS(Da):19,478

GeneID:24324

Synonyms:Endothelin-2;Et2;ET-2;PPET2;Preproendothelin-2;RNEDN2S01;Vasoactive intestinal contractor;VIC

Gene names:Edn2

Standard solution:320ng/L