Rat CREB Binding Protein,CREBBP ELISA KIT

SKU: E2595Ra

Size:96 Tests-1 Kit

Background:Acetylates histones, giving a specific tag for transcriptional activation (By similarity). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (By similarity). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (By similarity). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (By similarity). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (By similarity). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (By similarity). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (By similarity). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (By similarity). {ECO:0000250|UniProtKB:P45481, ECO:0000250|UniProtKB:Q92793}.

Research_area:

Applications:ELISA

Target_protein:Crebbp

Reactivity:Rat

Assay type:Sandwich

Sensitivity:0.019ng/ml

Detection range:0.05-15ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:CREB Binding Protein

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q6JHU9

MASS(Da):265424

GeneID:

Synonyms:Crebbp Cbp

Gene names:Crebbp

Standard solution:16ng/ml