Rat Advanced Glycosylation End Product-specific Receptor, AGER ELISA Kit

SKU: E1851Ra

Size:96 Tests-1 Kit

Background:Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides (By similarity). Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.

Research_area:Neuroscience

Applications:ELISA

Target_protein:AGER

Reactivity:Rat

Assay type:Sandwich

Sensitivity:9.14ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Advanced glycosylation end product-specific receptor

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q63495

MASS(Da):42,664

GeneID:81722

Synonyms:Advanced glycosylation end product-specific receptor;AGER;RAGE;Receptor for advanced glycosylation end products

Gene names:Ager

Standard solution:4800ng/L