Rat 5-Hydroxytryptamine Receptor 2B, HTR2B ELISA Kit

SKU: E1836Ra

Size:96 Tests-1 Kit

Background:G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed: 1505525, PubMed: 1331748). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances (PubMed: 22525520). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed: 1505525, PubMed: 1331748). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores (By similarity). Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. Plays a role in the regulation of behavior, including impulsive behavior. Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine (By similarity). May play a role in the perception of pain (PubMed: 22525520).

Research_area:Neuroscience

Applications:ELISA

Target_protein:HTR2B

Reactivity:Rat

Assay type:Sandwich

Sensitivity:5.13ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:5-Hydroxytryptamine Receptor 2B

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P30994

MASS(Da):53,652

GeneID:29581

Synonyms:5-HT2B;5-HT-2B;5-HT-2F;5-hydroxytryptamine receptor 2B;HTR 2B;HTR2B;Serotonin receptor 2B;Stomach fundus serotonin receptor

Gene names:HTR2B

Standard solution:2400ng/L