Rad50(Phospho-Ser635) Rabbit Polyclonal Antibody

SKU: BT-AP04379

Size:100μL

Background:The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50| a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein| cooperating with its partners| is important for DNA double-strand break repair| cell cycle checkpoint activation| telomere maintenance| and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.

Research_area:Epigenetics and nuclear signaling

Target_protein:RAD50

applications:WB

Reactivity:Human, Rat, Mouse

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:Rad50

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):

UniProt accession:Human: Q92878; Mouse: P70388; Rat: Q9JIL8

Synonyms:Rad50 ;Ser635; DNA repair protein RAD50; hRAD50; EC 3.6.-.-

GeneID:Human: 10111; Rat: 64012