Rabbit Tumor Necrosis Factor Α, TNF-A ELISA Kit

SKU: E0065Rb

Size:96 Tests-1 Kit

Background:Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (By similarity). The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.

Research_area:Immunology

Applications:ELISA

Target_protein:TNFA

Reactivity:Rabbit

Assay type:Sandwich

Sensitivity:0.24ng/L

Detection range:0.5-200ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Tumor Necrosis Factor alpha

Species:Rabbit

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P04924

MASS(Da):25817

GeneID:100009088

Synonyms:Cachectin;C-domain 1;C-domain 2;ICD1;ICD2;Intracellular domain 1;Intracellular domain 2;membrane form;N-terminal fragment;NTF ;soluble form;TNF A;TNF alpha;TNFA;TNF-a;TNF-alpha;Tumor necrosis factor;Tumor necrosis factor ligand superfamily member 2

Gene names:TNFA

Standard solution:240ng/L