PTPRM Monoclonal Antibody

SKU: BT-MCA2744

Size:100μL

Background:The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms.

Research_area:Signal transduction

Target_protein:PTPRM

applications:

Reactivity:Human

Clonality:Monoclonal

Clone ID:1H6D10

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:PTPRM

Immunogen:Purified recombinant fragment of human PTPRM (AA: extra 565-742) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):163.7kDa

UniProt accession:P28827

Synonyms:RPTPM, RPTPU, PTPRL1, hR-PTPu, R-PTP-MU

GeneID:5797