PTHLH Antibody - Cat. #: CSB-PA018991LA01HU

SKU: CSB-PA018991LA01HU

Size :50ug

Clone Number:

Aliases:HHM antibody; MGC14611 antibody; Osteostatin antibody; Parathyroid hormon like hormone isoform 2 preproprotein antibody; Parathyroid hormone like hormone antibody; Parathyroid hormone like hormone isoform 1 preproprotein antibody; Parathyroid hormone like protein antibody; Parathyroid hormone like related protein antibody; Parathyroid hormone related protein antibody; Parathyroid hormone-like protein antibody; Parathyroid like protein antibody; PLP antibody; PTH related protein antibody; PTH-rP antibody; PTHLH antibody; PTHR antibody; PTHR_HUMAN antibody; PTHrP antibody; PTHrP[107-139] antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P12272

Immunogen:Recombinant Human Parathyroid hormone-related protein (37-175AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath By similarity. Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:PTHLH

Research Areas:Cell biology; Signal transduction