PRNP Antibody - Cat. #: CSB-PA018739LA01HU

SKU: CSB-PA018739LA01HU

Size :50ug

Clone Number:

Aliases:Alternative prion protein, major prion protein antibody; AltPrP antibody; ASCR antibody; CD230 antibody; CD230 antigen antibody; CJD antibody; GSS antibody; KURU antibody; Major prion protein antibody; p27 30 antibody; PRIO_HUMAN antibody; Prion protein antibody; Prion related protein antibody; PRIP antibody; PRNP antibody; PrP antibody; PrP27 30 antibody; PrP27-30 antibody; PrP33-35C antibody; PrPC antibody; PrPSc antibody; Sinc antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P04156

Immunogen:Recombinant Human Major prion protein (23-64AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background:Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as a agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:PRNP

Research Areas:Neuroscience; Stem cells