PRMT5 Polyclonal Antibody

SKU: E-AB-12625

Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:PRMT5

Target Synonym:72 kDa ICln binding protein;72 kDa ICln-binding protein;ANM5;Histone synthetic lethal 7;S. cerevisiae;homolog of;Histone-arginine N-methyltransferase PRMT5;HMT1 hnRNP methyltransferase like 5;HOMOLOG OF;SKB1;HRMT1L5;IBP72;Jak-binding protein 1;JBP 1;JBP1;PRMT 5;PRMT5;Protein arginine methyltransferase 5;Protein arginine N methyltransferase 5;Protein arginine N methyltransferase 5 N terminally processed;Protein arginine N-methyltransferase 5;S. POMBE;S. POMBE HOMOLOG OF;SKB1;SHK1 KINASE BINDING PROTEIN 1;Shk1 kinase binding protein 1 homolog;Shk1 kinase-binding protein 1 homolog;Shk1 kinase/binding protein 1;S. pombe;homolog of;SKB 1;SKB1;SKB1 homolog;SKB1: SKB1 homolog (S. pombe);SKB1Hs

Research Areas:Cancer;Epigenetics and Nuclear Signaling

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:O14744

Accession:

Background:Protein arginine methyltransferase 5 has been shown to interact with WD repeat-containing protein 77, CLNS1A, Janus kinase 2, SNRPD3 and SUPT5H.Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation.

Concentration:0.3 mg/mL

Immunogen:Synthetic peptide of human PRMT5

Buffer:PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method:Affinity purification

Dilution:WB 1:200-1:1000

Calculated MW:71kDa

ObservedMW: