PRKAR2A Polyclonal Antibody

SKU: E-AB-52196

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: PRKAR2A

Target Synonym: cAMP dependent protein kinase regulatory subunit alpha 2;cAMP dependent protein kinase regulatory subunit RII alpha;cAMP dependent protein kinase type II alpha regulatory chain;cAMP dependent protein kinase type II alpha regulatory subunit;cAMP-dependent protein kinase type II-alpha regulatory subunit;KAP2;KAP2;MGC3606;PKR 2;PKR2;PRKA R2;PRKAR 2;PRKAR2;PRKAR2A;Protein kinase A RII alpha subunit;Protein kinase cAMP dependent regulatory type II alpha

Research Areas: Cancer;Metabolism;Signal Transduction

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human

Application: WB;IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: P13861

Accession:

Background: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER).

Concentration: 0.8 mg/mL

Immunogen: Fusion protein of human PRKAR2A

Buffer: PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Purification method: Antigen affinity purification

Dilution: WB 1:500-1:2000;IHC 1:35-1:200

Calculated MW: 46 kDa

ObservedMW: Refer to figures