PRKAG3 Antibody - Cat. #: CSB-PA883379ESR2HU

SKU: CSB-PA883379ESR2HU

Size :50ul

Clone Number:

Aliases:5 AMP activated protein kinase subunit gamma 3 antibody; 5''-AMP-activated protein kinase subunit gamma-3 antibody; AAKG3_HUMAN antibody; AMPK gamma 3 chain antibody; AMPK gamma3 antibody; AMPK subunit gamma-3 antibody; AMPKG3 antibody; PRKAG3 antibody; Protein kinase AMP activated gamma 3 non catalytic subunit antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9UGI9

Immunogen:Recombinant Human 5\\\'-AMP-activated protein kinase subunit gamma-3 protein (1-210AA)

Raised in:Rabbit

Species Reactivity:Human, Rat

Tested Applications:ELISA, WB; Recommended dilution: WB:1:500-1:2000

Background:AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:PRKAG3

Research Areas:Cancer; Cardiovascular; Metabolism; Signal transduction