POLR3K antibody , Cat. # FNab06634

SKU: FNab06634

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs(EBERs) induce type I interferon and NF-Kappa-B through the RIG-I pathway(By similarity).

Immunogen:polymerase(RNA) III(DNA directed) polypeptide K, 12.3 kDa

Synonyms:C11, C11 RNP3, hRPC11, HsC11p, My010, POLR3K, RNA polymerase III subunit C10, RNA polymerase III subunit C11, RPC10, RPC11, RPC12.5

Observed MW:12 kDa

Uniprot ID:Q9Y2Y1

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, IHC, IF, WB

Recommended dilution:WB: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:50-1:500

Gene ID:51728

Research Area:Immunology, Metabolism