POLR2D Antibody, FITC conjugated - Cat. #: CSB-PA018331LC01HU

SKU: CSB-PA018331LC01HU

Size :50ug

Clone Number:

Aliases:DNA directed RNA polymerase II 16 kDa polypeptide antibody; DNA directed RNA polymerase II subunit D antibody; DNA directed RNA polymerase II subunit RPB4 antibody; DNA-directed RNA polymerase II 16 kDa polypeptide antibody; DNA-directed RNA polymerase II subunit D antibody; DNA-directed RNA polymerase II subunit rpb4 antibody; HSRBP4 antibody; HSRPB4 antibody; polr2d antibody; polymerase RNA II DNA directed polypeptide D antibody; RBP4 antibody; RNA polymerase II 16 kDa subunit antibody; RNA polymerase II subunit B4 antibody; RNA polymerase II subunit D antibody; RNA polymerase II subunit hsRBP4 antibody; RPB16 antibody; RPB4_HUMAN antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O15514

Immunogen:Recombinant Human DNA-directed RNA polymerase II subunit RPB4 protein (1-142AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:

Background:DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:FITC

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:POLR2D

Research Areas:Epigenetics and Nuclear Signaling