PMAIP1 Monoclonal Antibody

SKU: BT-MCA4479

Size:100μL

Background:The protein encoded by this gene promotes activation of caspases and apoptosis, Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.

Research_area:Others

Target_protein:PMAIP1

applications:FCM

Reactivity:

Clonality:Monoclonal

Clone ID:1A2D3

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:PMAIP1

Immunogen:Purified recombinant fragment of human PMAIP1 (AA: 1-54) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):6kDa

UniProt accession:Q13794

Synonyms:APR, NOXA

GeneID:5366