PLAU Antibody - Cat. #: CSB-PA960570

SKU: CSB-PA960570

Size :50ul

Clone Number:

Aliases:ATF antibody; ATF uPA antibody; BDPLT5 antibody; Plasminogen activator antibody; Plasminogen activator urinary antibody; Plasminogen activator urokinase antibody; PLAU antibody; QPD antibody; u PA antibody; U plasminogen activator antibody; u-PA antibody; U-plasminogen activator antibody; uPA antibody; URK antibody; UROK_HUMAN antibody; Urokinase plasminogen activator antibody; Urokinase type plasminogen activator antibody; Urokinase type plasminogen activator precursor antibody; Urokinase-type plasminogen activator chain B antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P00749

Immunogen:Fusion protein of Human PLAU

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; ELISA:1:1000-1:2000, IHC:1:10-1:50

Background:This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen affinity purification

Conjugate:Non-conjugated

Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:PLAU

Research Areas:Cardiovascular